Pyridine-2-carboxylic acid as an effectual catalyst for rapid multi-component synthesis of pyrazolo[3,4-<i>b</i>]quinolinones
Mayank G. Sharma, Ruturajsinh M. Vala, Hitendra M. Patel
Abstract
]quinolinones in excellent yield (84-98%). Recyclization of the catalyst was also investigated. The electronic effect of the various substituents in aromatic rings indicated that the reaction proceeded through the carbocation intermediate. This newly designed protocol very quickly constructed products conventionally under milder conditions.
Topics & Concepts
PyridineCatalysisComponent (thermodynamics)ChemistryCarboxylic acidCombinatorial chemistryOrganic chemistryThermodynamicsPhysicsMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds