Incorporation of a Cp*Rh(III)-dithiophosphate Cofactor with Latent Activity into a Protein Scaffold Generates a Biohybrid Catalyst Promoting C(sp<sup>2</sup>)–H Bond Functionalization
Shunsuke Kato, Akira Onoda, Alexander R. Grimm, Kengo Tachikawa, Ulrich Schwaneberg, Takashi Hayashi
Abstract
)-H bond activation. This catalytic activity is enhanced 2.3-fold with the introduction of two glutamate residues (A100E/L125E) adjacent to the Cp*Rh(III) cofactor. The Cp*Rh(III) cofactor with switchable activity from a "latent" form to an "active" form provides a new strategy for generating biohybrid catalysts incorporating a variety of highly reactive transition metal complexes specifically within its protein scaffolds.
Topics & Concepts
ChemistryCatalysisCovalent bondStereochemistryRhodiumCofactorTetrahydrothiopheneCombinatorial chemistryLigand (biochemistry)Active siteOrganic chemistryEnzymeBiochemistryReceptorCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis