Breakthrough of solid tumor treatment: CAR-NK immunotherapy
Wenkang Wang, Yang Liu, Zhen He, Lifeng Li, Senbo Liu, Mingqiang Jiang, Bing Zhao, Meng Deng, Wendong Wang, Xuefang Mi, Zhenqiang Sun, Xin Ge, Zhenqiang Sun, Xin Ge
Abstract
As the latest and most anticipated method of tumor immunotherapy, CAR-NK therapy has received increasing attention in recent years, and its safety and high efficiency have irreplaceable advantages over CAR-T. Current research focuses on the application of CAR-NK in hematological tumors, while there are fewer studies on solid tumor. This article reviews the process of constructing CAR-NK, the effects of hypoxia and metabolic factors, NK cell surface receptors, cytokines, and exosomes on the efficacy of CAR-NK in solid tumor, and the role of CAR-NK in various solid tumor. The mechanism of action and the research status of the potential of CAR-NK in the treatment of solid tumor in clinical practice, and put forward the advantages, limitations and future problems of CAR-NK in the treatment of solid tumor.