Elevated NOX4 promotes tumorigenesis and acquired EGFR-TKIs resistance via enhancing IL-8/PD-L1 signaling in NSCLC
Wenjing Liu, Lin Wang, Feng-Mei Zhou, Shuwen Liu, Wei Wang, Erjiang Zhao, Quan-Jun Yao, Wei Li, Yanqiu Zhao, Zhi Shi, Jian-Ge Qiu, Bing‐Hua Jiang
Topics & Concepts
GefitinibGene knockdownOsimertinibCancer researchNOX4Epidermal growth factor receptorDownregulation and upregulationBiologyMedicineNADPH oxidaseCell biologyReceptorInternal medicineCell cultureErlotinibReactive oxygen speciesGeneticsGeneBiochemistryImmune cells in cancerNeutrophil, Myeloperoxidase and Oxidative MechanismsCancer Immunotherapy and Biomarkers