Preparation of nanoscale cationic metal–organic framework Nano Mn(<scp>iii</scp>)-TP for theranostics based on valence changes
Shijiang Yu, Hongliu Yu, Panpan Si, Zhen Wang, Bing Wang, Wenxin Lin
Abstract
-weighted MRI performance and Fenton-like effect due to valence changes of the Mn ions. Meanwhile, MTXNa@Nano Mn(III)-TP was obtained by loading with the anionic anticancer drug methotrexate disodium (MTXNa), and it could release MTXNa specifically in GSH solution with different pH values and temperatures, resulting in an improvement in the tumor suppressive effect of the Nano Mn(III)-TP. Based on the nanoplatform, the effective combination of magnetic resonance imaging (MRI), CDT and chemotherapy could be used as a potential therapeutic agent for multimodal therapy, which is also expected to be applied to clinical tumor treatment.
Topics & Concepts
SchematicNanoscopic scaleCationic polymerizationValence (chemistry)Nano-Materials scienceNanotechnologyMetalChemistryPolymer chemistryMetallurgyComposite materialEngineeringOrganic chemistryElectronic engineeringMetal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranosticsAdvanced Nanomaterials in Catalysis