Membrane-type 1 Matrix Metalloproteinase Modulates Tissue Homeostasis by a Non-proteolytic Mechanism
Mukundan Attur, Cuijie Lu, Xiaodong Zhang, Tianzhen Han, Cassidy Alexandre, Cristina Valacca, Shuai Zheng, Sarina Meikle, Branka Dabovic, Evelyne Tassone, Qing Yang, Victoria Kolupaeva, Shoshana Yakar, Steven B. Abramson, Paolo Mignatti
Abstract
demonstration that MT1-MMP modulates bone, cartilage, and fat homeostasis by controlling SSC differentiation through a mechanism independent of proteolysis.
Topics & Concepts
HomeostasisMatrix metalloproteinaseChemistryCell biologyMechanism (biology)Proteolytic enzymesMetalloproteinaseBiophysicsMatrix (chemical analysis)BiochemistryBiologyEnzymePhilosophyEpistemologyChromatographyProtease and Inhibitor MechanismsBlood Coagulation and Thrombosis MechanismsSignaling Pathways in Disease