Qbd based and Box-Behnken design assisted Oral delivery of stable lactone (active) form of Topotecan as PLGA nanoformulation: Cytotoxicity, pharmacokinetic, in vitro, and ex vivo gut permeation studies
Tahir Khuroo, Arshad Khuroo, Afzal Hussain, Mohd. Aamir Mirza, Amulya K. Panda, Javid Wani, Zeenat Iqbal
Topics & Concepts
TopotecanBioavailabilityChemistryEx vivoZeta potentialPLGAPermeationPharmacokineticsIn vivoIn vitroNuclear chemistryPharmacologyNanoparticleNanotechnologyMaterials scienceMembraneBiochemistryMedicineChemotherapyBiotechnologySurgeryBiologyRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesCancer therapeutics and mechanisms