Characterization of Immunological Responses to<i>Borrelia</i>Immunogenic Protein A (BipA), a Species-Specific Antigen for North American Tick-Borne Relapsing Fever
Michael W. Curtis, Aparna Krishnavajhala, Alexander R. Kneubehl, Monica E. Embers, Jenna R. Gettings, Michael J. Yabsley, Job E. López
Abstract
Borrelia species transmitted by soft or hard ticks cause tick-borne relapsing fever (TBRF). This is a debilitating disease distributed worldwide but is likely underdiagnosed or misdiagnosed as Lyme disease due to poorly developed diagnostic tests. Borrelia turicatae , Borrelia parkeri , and Borrelia hermsii are three TBRF species previously implicated in human disease in North America.
Topics & Concepts
relapsing feverBorreliaBiologyLyme diseaseVirologySpirochaetaceaeBorrelia burgdorferiAntibodyAntigenMicrobiologyImmunologyVector-borne infectious diseasesViral Infections and VectorsMosquito-borne diseases and control