Rapid and label-free cancer theranostics <i>via in situ</i> bio-self-assembled DNA–gold nanostructures loaded exosomes
Farouk Semcheddine, Nida El Islem Guissi, Weiwei Liu, Tayyaba, Gang Lv, Hui Jiang, Xuemei Wang
Abstract
In situ ex vivo bio-self-assembled ring-shaped DNA–Au nanostructures and DNA–Au nanostructures loaded exosomes with strong dual fluorescence and rapid cellular uptake, reaching the nucleus 10 min post-incubation as an outstanding theranostic platform.
Topics & Concepts
MicrovesiclesCancer cellNanotechnologyIn vivoColloidal goldBiocompatibilityDNADrug deliveryIn vitroCancerAptamerNanomedicineBiophysicsChemistryMaterials scienceCancer researchMolecular biologyNanoparticleBiologymicroRNABiochemistryOrganic chemistryGeneticsBiotechnologyGeneExtracellular vesicles in diseaseAdvanced biosensing and bioanalysis techniquesGold and Silver Nanoparticles Synthesis and Applications