An overview on 2-indolinone derivatives as anticancer agents
Samy M. Ibrahim, Ahmed S. Abdelkhalek, Shaban A. A. Abdel‐Raheem, Nada E. Freah, Nada H. El Hady, Nada K. Aidia, Nada A. Tawfeq, Nora I. Gomaa, Nora M. Fouad, Hager A. Salem, Hager M. Ibrahim, Mahmoud M. Sebai
Abstract
2-Indolinone nucleus is considered one of a promising heterocyclic core in medicinal chemistry that showed numerous range of activity among which antimicrobial, antioxidant, antiviral, antitubercular and anticancer activities. Cancer targeting is still an issue so there is a need for developing new agents that inhibit cancer growth without or low effect on normal body cells. Some derivatives of indolin-2-one are known to be a critical structure in some inhibitors of receptor tyrosine kinases (RTKs); a cancer target therapy, for example, Sunitinib. Herein in this review we focus on 2-indolinone derivatives as RTKs inhibitors as cancer targeting therapy.