T cell Immunoglobulin and Mucin Domain Containing Protein 3 (TIM-3) Inhibitors in Oncology Clinical Trials: A Review
Benjamin Q. Duong, Pratyush Banskota, Gerald S. Falchook
Abstract
T cell immunoglobulin and mucin domain containing protein 3 (TIM-3) is a receptor found on a multitude of immune cells and is commonly overexpressed in patients with cancer. Due to its selective expression in immune cells and its preliminary efficacy in preclinical models, TIM-3 is a promising target as a treatment for cancer. Both monotherapy and combination regimens are being developed and are currently under investigation. This clinical review seeks to summarize and compile past, present, and future TIM-3 inhibitors in clinical trials.
Topics & Concepts
MucinAntibodyDomain (mathematical analysis)Clinical trialCancer researchMedicineInternal medicineOncologyComputational biologyChemistryImmunologyBiologyPathologyMathematicsMathematical analysisGalectins and Cancer BiologyGlycosylation and Glycoproteins ResearchMonoclonal and Polyclonal Antibodies Research