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Design and synthesis of new 1,4,5-trisubstituted triazole-bearing benzenesulphonamide moiety as selective COX-2 inhibitors

Mohamed S. Bekheit, Hanan A. Mohamed, Bakr F. Abdel‐Wahab, Marwa A. Fouad

2021Medicinal Chemistry Research30 citationsDOI

Topics & Concepts

ChemistryPharmacophoreMoietyStereochemistrySelectivityTriazole1,2,3-TriazoleIn silicoIn vitroHydrazideCombinatorial chemistryBiochemistryOrganic chemistryCatalysisGeneSynthesis and biological activityClick Chemistry and ApplicationsInflammatory mediators and NSAID effects
Design and synthesis of new 1,4,5-trisubstituted triazole-bearing benzenesulphonamide moiety as selective COX-2 inhibitors | Litcius