Newly Synthesized Pyrazolinone Chalcones as Anticancer Agents via Inhibiting the PI3K/Akt/ERK1/2 Signaling Pathway
Ahmed A. Noser, Ihsan A. Shehadi, Aboubakr H. Abdelmonsef, Maha M. Salem
Abstract
obeyed Lipinski's rule of five and might be used as a favored scaffold for cancer treatment by inhibiting proliferation and metastasis via inhibition of the PI3K/Akt and Raf-1/ERK1/2 signaling pathways.
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BChemistryLipinski's rule of fiveCancer researchCancer cellCell cycle checkpointSignal transductionCell cycleCell biologyBiochemistryApoptosisIn silicoBiologyCancerGeneGeneticsSynthesis and biological activityQuinazolinone synthesis and applicationsMelanoma and MAPK Pathways