Oridonin alleviates kanamycin-related hearing loss by inhibiting NLRP3/caspase-1/gasdermin D-induced inflammasome activation and hair cell pyroptosis
Liyuan Wu, Mengbing Chen, Meng-Hua Li, Yifeng Wang, Yalan Li, Liting Zheng, Zhaoyang Ke, Ke Liu, Yuehua Qiao, Xi Shi
Topics & Concepts
PyroptosisInflammasomeCaspase 1Hair cellPyrin domainWestern blotInflammationProgrammed cell deathHearing lossChemistryCaspaseCell biologyApoptosisMedicineCochleaImmunologyBiologyBiochemistryAudiologyGeneInflammasome and immune disordersImmune Response and InflammationIon Channels and Receptors