Synthesis of Polycyclic Quinazolinones through C(sp<sup>3</sup>)−H Functionalization of Inert Alkanes or Visible‐Light‐Promoted Oxidation Decarboxylation of <i>N</i>‐Hydroxyphthalimide Esters
Weikang Zhang, Jiao‐Zhe Li, Cancan Zhang, Jian Zhang, Yan‐Nan Zheng, Yufang Hu, Ting Li, Wen‐Ting Wei
Abstract
Abstract Two novel C(sp 3 )−H functionalization of inert alkanes and visible‐light promoted oxidation decarboxylation of N ‐hydroxyphthalimide (NHP) esters to access polycyclic quinazolinones have been described. These methods do not involve metal catalysts and are carried out in water or water/DMSO media. The wide substrate scope, even including the seven‐membered ring under mild reaction conditions, demonstrate the practicability of these strategies.
Topics & Concepts
ChemistryDecarboxylationInertSurface modificationSubstrate (aquarium)CatalysisInert gasVisible spectrumOrganic chemistryCombinatorial chemistryPhotochemistryGeologyOptoelectronicsOceanographyPhysicsPhysical chemistryCatalytic C–H Functionalization MethodsQuinazolinone synthesis and applicationsRadical Photochemical Reactions