Formulation and evaluation of β-cyclodextrin-mediated inclusion complexes of isoniazid scaffolds: molecular docking and <i>in vitro</i> assessment of antitubercular properties
Lincy Tom, Christy Rosaline Nirmal, Azger Dusthackeer, B. Magizhaveni, M.R. Prathapachandra Kurup
Abstract
Inclusion complexes of isoniazid derivatives with β-CD were synthesized and their potent antitubercular properties were studied.
Topics & Concepts
ChemistryCyclodextrinDocking (animal)In vitroIsoniazidCombinatorial chemistryOrganic chemistryBiochemistryTuberculosisMedicineNursingPathologySynthesis of Tetrazole DerivativesComputational Drug Discovery MethodsSynthesis and Reactivity of Heterocycles