lncRNA MIRF Promotes Cardiac Apoptosis through the miR-26a-Bak1 Axis
Xiaomin Su, Lifang Lv, Yue Li, Ruonan Fang, Rui Yang, Chao Li, Tianyu Li, Di Zhu, Xuelian Li, Yuhong Zhou, Hongli Shan, Haihai Liang
Abstract
-induced cardiac apoptosis, which was abolished by miR-26a inhibitor. Taken together, these results suggested that MIRF contributed to cardiomyocyte apoptosis through modulating Bak1 by regulation of miR-26a, which can be a potential therapeutic target for the treatment of ischemic heart disease.
Topics & Concepts
ApoptosisMyocardial infarctionGene silencingDownregulation and upregulationMedicineProgrammed cell deathmicroRNAAutophagyInternal medicineCardiologyMitochondrionCancer researchPharmacologyCell biologyBiologyGeneBiochemistryCancer-related molecular mechanisms researchAutophagy in Disease and TherapyMicroRNA in disease regulation