Selection of CHO host and recombinant cell pools by inhibition of the proteasome results in enhanced product yields and cell specific productivity
Tanya J. Knight, Sarah J. Turner, Colin Jaques, C. Mark Smales
Topics & Concepts
Chinese hamster ovary cellProteasomeRecombinant DNACell biologyCell cultureBiologyCellMonoclonal antibodyEndoplasmic-reticulum-associated protein degradationProtein degradationChemistryBiochemistryAntibodyUnfolded protein responseEndoplasmic reticulumGeneImmunologyGeneticsViral Infectious Diseases and Gene Expression in InsectsVirus-based gene therapy researchTransgenic Plants and Applications