NF-κB pathway activation by Octopus peptide hydrolysate ameliorates gut dysbiosis and enhances immune response in cyclophosphamide-induced mice
Muhsin Ali, Hidayat Ullah, Nabeel Ahmed Farooqui, Ting Deng, Nimra Zafar Siddiqui, Muhammad Ilyas, Sharafat Ali, Mujeeb Ur Rahman, Ata Ur Rehman, Yamina Alioui, Liang Wang, Yi Xin
Abstract
, and reversed the ecological equilibrium of the gut microflora. The findings revealed that OPH serves as a prebiotic to prevent CTX-mediated disruption in the intestinal barrier and boosts gut mucosal immunity by attenuating gut microflora imbalance, implying that OPH could be used as an immunological ingredient in nutritious foods to regulate the immune system and protect the gut from inflammatory diseases.
Topics & Concepts
Immune systemHydrolysateDysbiosisCyclophosphamideoctopus (software)PeptideImmunologyChemistryGut floraMicrobiologyBiologyMedicineInternal medicineBiochemistryHydrolysisChemotherapyComputational chemistryProtein Hydrolysis and Bioactive PeptidesBiochemical effects in animalsStress Responses and Cortisol