Identifying Effective Durations of Antibiotic Therapy for the Treatment of Carbapenem-resistant Enterobacterales Bloodstream Infections: A Multicenter Observational Study
Caitlin Soto, Alice J. Hsu, Jae Hyoung Lee, Kathryn Dzintars, Rebecca Choudhury, Timothy C Jenkins, Erin K McCreary, Katelyn Quartuccio, Erica Stohs, Matty Zimmerman, Pranita D. Tamma
Abstract
In a propensity-score-weighted cohort of 183 adults with carbapenem-resistant Enterobacterales bacteremia at 24 US hospitals, patients receiving short courses of active therapy (7-10 days, median 9 days) experienced similar odds of recurrent bacteremia or death within 30 days as those receiving prolonged courses of active therapy (14-21 days, median 14 days).
Topics & Concepts
BacteremiaMedicineObservational studyCarbapenemBloodstream infectionInternal medicineOdds ratioCohortAntibioticsPropensity score matchingCohort studyAntibiotic therapyMulticenter studyOddsIntensive care medicineLogistic regressionRandomized controlled trialMicrobiologyBiologyAntibiotic Resistance in BacteriaAntibiotic Use and ResistanceAntibiotics Pharmacokinetics and Efficacy