Nicotine induces senescence in spermatogonia stem cells by disrupting homeostasis between circadian oscillation and rhythmic mitochondrial dynamics via the SIRT6/Bmal1 pathway
Zelin Zhang, Zhongliang Jiang, Jianyong Cheng, Christopher A. Price, Li Yang, Qingwang Li
Topics & Concepts
SenescenceBiologySIRT6Cell biologyNicotineStem cellCircadian rhythmMitochondrionPremature agingOxidative stressDownregulation and upregulationSirtuinEndocrinologyAcetylationGeneticsNeuroscienceGeneSirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsSperm and Testicular Function