Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells
Savan K. Patel, Margaret M. Billingsley, C. Pritchett Frazee, Xuexiang Han, Kelsey L. Swingle, Jingya Qin, Mohamad‐Gabriel Alameh, Karin Wang, Drew Weissman, Michael J. Mitchell
Topics & Concepts
EndosomeChemistryEndocytic cycleNucleic acidGene deliveryEndocytosisCholesterolDrug deliveryIn vivoBiochemistryCellCell biologyTransfectionBiologyGeneBiotechnologyOrganic chemistryRNA Interference and Gene DeliveryLipid Membrane Structure and BehaviorImmunotherapy and Immune Responses