A porphysome-based photodynamic O<sub>2</sub> economizer for hypoxic tumor treatment by inhibiting mitochondrial respiration
Rongrong Zheng, Xia‐Yun Chen, Linping Zhao, Yang Ni, Runtian Guan, Ali Chen, Xiyong Yu, Hong Cheng, Chang Wang, Shiying Li
Abstract
A porphysome-based photodynamic O2 economizer (P-PAT) is prepared for hypoxic tumor therapy. The self-assembled porphyrin bilayers of P-PAT possess high loading capacity to atovaquone (ATO) (nearly 70%), which could restrain mitochondrial respiration to relieve hypoxia and enhance photodynamic therapy.
Topics & Concepts
RespirationChemistryMitochondrionPhotodynamic therapyHypoxia (environmental)Cancer researchBiochemistryBiologyOxygenOrganic chemistryAnatomyNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesCancer, Hypoxia, and Metabolism