Litcius/Paper detail

Rational design, synthesis, antiproliferative activity against MCF-7, MDA-MB-231 cells, estrogen receptors binding affinity, and computational study of indenopyrimidine-2,5-dione analogs for the treatment of breast cancer

Iqra Ejaz, Muhammad Aamir Javed, Muhammad Saeed Jan, Muhammad Ikram, Abdul Sadiq, Sajjad Ahmad, Umer Rashid

2022Bioorganic & Medicinal Chemistry Letters17 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryEstrogen receptorMCF-7MTT assayCytotoxicityReceptorIC50HEK 293 cellsCancer cellDocking (animal)Ligand binding assayStereochemistryBiochemistryIn vitroBreast cancerCancerInternal medicineHuman breastNursingMedicineEstrogen and related hormone effectsSynthesis and biological activityBioactive Compounds and Antitumor Agents