Rational design, synthesis, antiproliferative activity against MCF-7, MDA-MB-231 cells, estrogen receptors binding affinity, and computational study of indenopyrimidine-2,5-dione analogs for the treatment of breast cancer
Iqra Ejaz, Muhammad Aamir Javed, Muhammad Saeed Jan, Muhammad Ikram, Abdul Sadiq, Sajjad Ahmad, Umer Rashid
Topics & Concepts
ChemistryEstrogen receptorMCF-7MTT assayCytotoxicityReceptorIC50HEK 293 cellsCancer cellDocking (animal)Ligand binding assayStereochemistryBiochemistryIn vitroBreast cancerCancerInternal medicineHuman breastNursingMedicineEstrogen and related hormone effectsSynthesis and biological activityBioactive Compounds and Antitumor Agents