Design and Synthesis of a Highly Selective and <i>In Vivo</i>-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins
Alex Preston, Stephen J. Atkinson, Paul Bamborough, Chun‐wa Chung, Peter D. Craggs, Laurie Gordon, Paola Grandi, James R. Gray, Emma J. Jones, Matthew Lindon, Anne‐Marie Michon, Darren J. Mitchell, Rab K. Prinjha, Francesco Rianjongdee, Inmaculada Rioja, Jonathan T. Seal, S. Taylor, Ian D. Wall, Robert J. Watson, James M. Woolven, Emmanuel H. Demont
Abstract
characterization.
Topics & Concepts
BromodomainIn vivoChemistryBET inhibitorBRD4In vitroComputational biologyPharmacologyCancer researchBiochemistryEpigeneticsBiologyGeneticsGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways