Litcius/Paper detail

Design and Synthesis of a Highly Selective and <i>In Vivo</i>-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins

Alex Preston, Stephen J. Atkinson, Paul Bamborough, Chun‐wa Chung, Peter D. Craggs, Laurie Gordon, Paola Grandi, James R. Gray, Emma J. Jones, Matthew Lindon, Anne‐Marie Michon, Darren J. Mitchell, Rab K. Prinjha, Francesco Rianjongdee, Inmaculada Rioja, Jonathan T. Seal, S. Taylor, Ian D. Wall, Robert J. Watson, James M. Woolven, Emmanuel H. Demont

2020Journal of Medicinal Chemistry53 citationsDOIOpen Access PDF

Abstract

characterization.

Topics & Concepts

BromodomainIn vivoChemistryBET inhibitorBRD4In vitroComputational biologyPharmacologyCancer researchBiochemistryEpigeneticsBiologyGeneticsGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways