A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance
Giulia Rossetti, Judith A. Ermer, Maike Stentenbach, Stefan J. Siira, Tara R. Richman, Dusanka Milenkovic, Kara L. Perks, Laetitia A. Hughes, Emma Jamieson, Gulibaikelamu Xiafukaiti, Natalie C. Ward, Satoru Takahashi, Nicola Gray, Helena M. Viola, Livia C. Hool, Oliver Rackham, Aleksandra Filipovska
Abstract
variant mice on a high-fat diet. Our findings reveal that the MRPP3 variant may be a predisposing factor to insulin resistance and metabolic disease in the human population.
Topics & Concepts
Insulin resistanceBiologyGeneMitochondrionInsulinSteatosisMitochondrial DNALipid metabolismEndocrinologyGeneticsInternal medicineMedicineMitochondrial Function and PathologyAdipose Tissue and MetabolismMetabolism and Genetic Disorders