Dual regulation of TRPV1 channels by phosphatidylinositol via functionally distinct binding sites
Aysenur Torun Yazici, Eleonora Gianti, Marina A. Kasimova, Bo Hyun Lee, Vincenzo Carnevale, Tibor Rohács
Abstract
was more stable than PtdIns in a previously identified, nonoverlapping, putative activating binding site. Our data indicate that phosphoinositides regulate channel activity via functionally distinct binding sites, which may explain some of the complexities of the effects of these lipids on TRPV1.
Topics & Concepts
TRPV1PhosphatidylinositolCapsaicinChemistryTransient receptor potential channelBinding siteCell biologyPhosphatidylinositol 4,5-bisphosphateAntagonistMutantBiochemistryBiophysicsReceptorSignal transductionBiologyGeneIon Channels and ReceptorsIon channel regulation and functionPhytochemicals and Antioxidant Activities