Angiotensin (1–7) protects against renal ischemia-reperfusion injury via regulating expression of NRF2 and microRNAs in Fisher 344 rats
Asif Zaman, Anees Ahmad Banday
Abstract
This is the first study to show that ANG(1-7) via Mas receptors could activate the redox-sensitive nuclear factor-erythroid factor 2-related factor 2 (NRF2)-phase II antioxidant system and protect against ischemia-reperfusion (I/R)-induced renal injury, identifying ANG(1-7), Mas receptor agonists, or NRF2 activators as potential therapeutic interventions to protect against renal and cardiovascular diseases. Moreover, miRNAs have differential expression in adult versus aged rats, and I/R modulates miRNA expression in both age groups, indicating their involvement in kidney disease.
Topics & Concepts
Renal ischemiamicroRNAIschemiaReceptorKidneyMedicinePharmacologyReperfusion injuryKidney diseaseAngiotensin IIInternal medicineEndocrinologyBiologyBiochemistryGeneRenin-Angiotensin System StudiesPregnancy and preeclampsia studiesMicroRNA in disease regulation