A biosynthesis pathway for 3-hydroxypropionic acid production in genetically engineered <i>Saccharomyces cerevisiae</i>
Tian Tong, Zhenyan Tao, Xiulai Chen, Cong Gao, Hui Liu, Xiaoling Wang, Gao‐Qiang Liu, Li Liu
Abstract
The oxaloacetate pathway using glucose as a substrate was developed to synthesize 3-HP. The intracellular ATP supply was enhanced to optimize the 3-HP production through a dephosphorylation regulation strategy.
Topics & Concepts
BiosynthesisDephosphorylationSaccharomyces cerevisiaeBiochemistryChemistryIntracellularSubstrate (aquarium)YeastOverproductionEnzymeBiologyPhosphataseEcologyMicrobial Metabolic Engineering and BioproductionEnzyme Catalysis and ImmobilizationBiofuel production and bioconversion