Vanillin and pentoxifylline ameliorate isoproterenol-induced myocardial injury in rats <i>via</i> the Akt/HIF-1α/VEGF signaling pathway
Mohamed M. Elseweidy, Sousou I. Ali, Mohamed A. Shaheen, Asmaa M. Abdelghafour, Sally K. Hammad
Abstract
were increased. Treatment with either Van or PTX ameliorated ISO-induced changes and further upregulated Akt/HIF-1α/VEGF signaling. Furthermore, Van + PTX combination was more effective than monotherapy. These findings suggest a novel therapeutic potential of Van and PTX in ameliorating MI through enhancing cardiac angiogenesis and modulating oxidative stress, inflammation and apoptosis.
Topics & Concepts
PentoxifyllineProtein kinase BPharmacologyChemistryVEGF receptorsSignal transductionPI3K/AKT/mTOR pathwayMedicineInternal medicineBiochemistryCardiac Ischemia and ReperfusionTraditional Chinese Medicine AnalysisNatural Products and Biological Research