Novel Vaccine That Blunts Fentanyl Effects and Sequesters Ultrapotent Fentanyl Analogues
Rodell C. Barrientos, Eric W. Bow, Connor Whalen, Oscar B. Torres, Agnieszka Sulima, Zoltán Beck, Arthur E. Jacobson, Kenner C. Rice, Gary R. Matyas
Abstract
, immunization shifted the antinociceptive dose-response curve of fentanyl to higher doses. Collectively, these preclinical results showcased the desired traits of a potential vaccine against fentanyl and demonstrated the feasibility of immunization to combat fentanyl-induced effects.
Topics & Concepts
FentanylPharmacologyMedicineAnesthesiaChemistryOpioid Use Disorder TreatmentPain Management and Opioid UseAnesthesia and Pain Management