The Mitochondrial‐Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy
Lihua Ni, Yuan Cheng
Abstract
The mitochondrial-associated endoplasmic reticulum membrane (MAM) is located between the outer mitochondrial membrane and the endoplasmic reticulum membrane. The MAM is involved in a wide range of cellular functions, including calcium signaling, the division and fusion of mitochondria, endoplasmic reticulum stress, and the synthesis and transport of lipids. Recent studies have discovered that the MAM is involved in the pathogenesis of diabetic nephropathy (DN). In this article, we summarize the structure, function and role of the MAM in DN. We hope this study will provide clues and a theoretical basis for mechanistic and targeted drug research on DN.
Topics & Concepts
Endoplasmic reticulumDiabetic nephropathyMitochondrionCell biologyMedicineChemistryBiologyEndocrinologyDiabetes mellitusMitochondrial Function and PathologyEndoplasmic Reticulum Stress and DiseaseAlzheimer's disease research and treatments