Residual Immunity from Smallpox Vaccination and Possible Protection from Mpox, China
Huang Yu, Li Guo, Yanan Li, Lili Ren, Jiqin Nie, Fengwen Xu, Tingxuan Huang, Jingchuan Zhong, Zhangling Fan, Yin Zhang, Yu Xie, Qiao Zhang, Shan Mei, Xiao Yan, Xinming Wang, Liuhui Xu, Fei Guo, Jianwei Wang
Abstract
Among persons born in China before 1980 and tested for vaccinia virus Tiantan strain (VVT), 28.7% (137/478) had neutralizing antibodies, 71.4% (25/35) had memory B-cell responses, and 65.7% (23/35) had memory T-cell responses to VVT. Because of cross-immunity between the viruses, these findings can help guide mpox vaccination strategies in China.
Topics & Concepts
VacciniaVaccinationVirologyImmunitySmallpoxImmunologyVirusSmallpox vaccineAntibodyMedicineChinaBiologyImmune systemGeographyGeneRecombinant DNABiochemistryArchaeologyPoxvirus research and outbreaksBacillus and Francisella bacterial researchImmunotherapy and Immune Responses