Bimodular effects of D614G mutation on the spike glycoprotein of SARS-CoV-2 enhance protein processing, membrane fusion, and viral infectivity
Xiaoyi Jiang, Zhengrong Zhang, Chenxi Wang, Hongguang Ren, Lihua Gao, Haoran Peng, Zubiao Niu, He Ren, Hongyan Huang, Qiang Sun
Topics & Concepts
InfectivityVirologyLipid bilayer fusionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Viral membraneMutationGlycoprotein2019-20 coronavirus outbreakMembrane glycoproteinsCoronavirus disease 2019 (COVID-19)Fusion proteinSpike (software development)BiologyComputational biologyChemistryMedicineMolecular biologyVirusBiochemistryViral envelopeComputer scienceRecombinant DNAGeneDiseasePathologySoftware engineeringOutbreakInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchBacteriophages and microbial interactionsViral gastroenteritis research and epidemiology