Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition
Mengzhen Zhou, Shi Tang
Abstract
Orexin is a neuropeptide produced by the lateral hypothalamus that plays an important role in regulating the sleep-wake cycle. The overexpression of the orexinergic system may be related to the pathology of sleep/wakefulness disorders in Alzheimer's disease (AD). In AD patients, the increase in cerebrospinal fluid orexin levels is associated with parallel sleep deterioration. Dual orexin receptor antagonist (DORA) can not only treat the sleep-wakefulness disorder of AD but also improve the performance of patients with cognitive behavior disorder. It is critical to clarify the role of the orexin system in AD, study its relationship with cognitive decline in AD, and evaluate the safety and efficacy of DORA.
Topics & Concepts
OrexinWakefulnessNarcolepsySleep (system call)Orexin-ANeuroscienceMedicineOrexin receptorAntagonistSleep disorderInternal medicineLateral hypothalamusReceptor antagonistPsychologyCognitionNeuropeptideEndocrinologyHypothalamusReceptorNeurologyElectroencephalographyComputer scienceOperating systemSleep and Wakefulness ResearchSleep and related disordersCircadian rhythm and melatonin