Vutrisiran in Transthyretin Amyloidosis
Ronald Witteles, Pablo García‐Pavía, Caroline Morbach, Julian D. Gillmore, Mark Taylor, Isabel Conceição, William B White, C. Kwok, Marianne T. Sweetser, Katherine L. Boyle, David Adams
Abstract
BACKGROUND: Vutrisiran is an RNA interference therapeutic that has demonstrated efficacy for the treatment of patients with transthyretin amyloidosis (ATTR) with polyneuropathy and cardiomyopathy in the phase 3 HELIOS-A and HELIOS-B studies, respectively. During the initial randomized treatment periods of these studies, vutrisiran was well tolerated and had an acceptable safety profile. OBJECTIVES: This pooled safety analysis aimed to evaluate the safety of vutrisiran in a large population of patients with hereditary ATTR and wild-type ATTR who received treatment for up to 58 months in HELIOS-A and HELIOS-B. METHODS: Data from patients who received at least one dose of vutrisiran at any time during the HELIOS-A or HELIOS-B studies were included in this pooled safety analysis. For reference, data from the external placebo arm of HELIOS-A (APOLLO placebo) and the placebo arm of HELIOS-B studies were included. Exposure-adjusted adverse event rates (AERs) and serious AERs were calculated per 100 patient-years. RESULTS: The combined vutrisiran group comprised 707 patients (HELIOS-A vutrisiran group: n = 160; HELIOS-B vutrisiran group: n = 547) with a mean age at symptom onset of 68.5 years; 30.3% had hereditary ATTR. These patients had a median (range) treatment duration of 33.4 months (0.0-57.8) and a cumulative exposure of 1,518.9 patient-years. In the combined vutrisiran group, AERs and serious AERs for specific adverse events were comparable to those reported in either of the placebo reference groups and those previously reported during the initial randomized treatment periods of the HELIOS-A and HELIOS-B studies. AERs for cardiac failure, the most common adverse event in vutrisiran-treated patients excluding COVID-19, were lower in the HELIOS-A and HELIOS-B vutrisiran groups than in the corresponding placebo groups. Injection-site reactions were infrequent and mild or moderate in severity. There were no ocular, hepatic, or renal safety concerns with vutrisiran treatment. CONCLUSIONS: In a broad population of patients with ATTR who were treated for up to 58 months, vutrisiran was well tolerated and had an acceptable safety profile, consistent with that previously reported for the HELIOS-A and HELIOS-B studies.