HIF-1α Hydroxyprolines Modulate Oxygen-Dependent Protein Stability Via Single VHL Interface With Comparable Effect on Ubiquitination Rate
Wenguang He, Sarah Batty-Stuart, Jeffrey E. Lee, Michael Ohh
Topics & Concepts
Ubiquitin ligaseHydroxylationUbiquitinProtein subunitHypoxia-inducible factorsChemistryHydroxyprolineProlineOxygen tensionBiochemistryDNA ligaseCell biologyOxygenBiophysicsBiologyAmino acidEnzymeGeneOrganic chemistryCancer, Hypoxia, and MetabolismUbiquitin and proteasome pathwaysMetabolism, Diabetes, and Cancer