Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties
Joana Reis, Carlos Fernandes, Hoda A. Salem, Marta Maia, Cláudia Tomé, Sofia Benfeito, José Teixeira, Paulo J. Oliveira, Eugenio Uriarte, Francesco Ortuso, Stefano Alcaro, Donatella Bagetta, Fernando Cagide, Fernanda Borges
Topics & Concepts
ChromoneChemistryMonoamine oxidaseCarboxamideDrugStereochemistryPharmacologyLead compoundIC50Monoamine oxidase BChemical synthesisDrug discoveryStructure–activity relationshipIn vitroBiochemistryEnzymeMedicineSynthesis of Organic CompoundsOxidative Organic Chemistry ReactionsClick Chemistry and Applications