Recent advances in the application of parahydrogen in catalysis and biochemistry
Gerd Buntkowsky, Franziska Theiß, Jonas Lins, Yuliya A. Miloslavina, Laura Wienands, Alexey S. Kiryutin, Alexandra V. Yurkovskaya
Abstract
. Parahydrogen induced polarization (PHIP) is an efficient and cost-effective hyperpolarization method, which has widespread applications in Chemistry, Physics, Biochemistry, Biophysics, and Medical Imaging. PHIP creates its signal-enhancements by means of a reversible (SABRE) or irreversible (classic PHIP) chemical reaction between the parahydrogen, a catalyst, and a substrate. Here, we first give a short overview about parahydrogen-based hyperpolarization techniques and then review the current literature on method developments and applications of various flavors of the PHIP experiment.
Topics & Concepts
Spin isomers of hydrogenHyperpolarization (physics)ChemistryCombinatorial chemistryNanotechnologyNuclear magnetic resonance spectroscopyMaterials scienceOrganic chemistryHydrogenAdvanced NMR Techniques and ApplicationsSolid-state spectroscopy and crystallographyAtomic and Subatomic Physics Research