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Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

David Gate, Naresha Saligrama, Olivia Leventhal, Andrew C. Yang, Michael S. Unger, Jinte Middeldorp, Kelly Chen, Benoit Lehallier, Divya Channappa, Mark B. De Los Santos, Alisha A. McBride, John V. Pluvinage, Fanny M. Elahi, Grace Tam, Yongha Kim, Michael D. Greicius, Anthony D. Wagner, Ludwig Aigner, Douglas Galasko, Mark M. Davis, Tony Wyss‐Coray

2020Nature999 citationsDOIOpen Access PDF

Topics & Concepts

ImmunologyImmune systemT-cell receptorNeuroinflammationCD8BiologyNeurodegenerationCytotoxic T cellAcquired immune systemCerebrospinal fluidAntigenAlzheimer's diseaseT cellDiseaseMedicineNeurosciencePathologyInflammationGeneticsIn vitroNeuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomicsTryptophan and brain disorders
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease | Litcius