How can we improve the design of small molecules to target thioredoxin reductase for treating cancer?
Jianqiang Xu, Jianguo Fang
Abstract
The ubiquitous thioredoxin reductase (TrxR, encoded by TXNRD gene) enzymes are essential to maintain the cellular redox homeostasis. The most outstanding function of TrxR is to keep its native subs...
Topics & Concepts
Thioredoxin reductaseThioredoxinFunction (biology)ReductaseBiologyComputational biologyEnzymeGeneCell biologyBiochemistryRedox biology and oxidative stressMetal-Catalyzed Oxygenation MechanismsEnzyme function and inhibition