Photofunctional cyclometallated iridium(<scp>iii</scp>) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications
Lili Huang, Peter Kam‐Keung Leung, Lawrence Cho‐Cheung Lee, Guang‐Xi Xu, Yun Wah Lam, Kenneth Kam‐Wing Lo
Abstract
We report herein near-infrared (NIR)-emitting cyclometallated iridium(III) complexes bearing a heteroaromatic methylsulfone moiety as sulfhydryl-specific reagents; one of the complexes was conjugated to cysteine and cysteine-containing peptides and proteins for bioimaging and photocytotoxic applications.
Topics & Concepts
BioconjugationIridiumChemistryCysteineMoietyReagentCombinatorial chemistryConjugated systemOrganic chemistryEnzymeCatalysisPolymerClick Chemistry and ApplicationsChemical Synthesis and AnalysisSynthesis and Catalytic Reactions