A modular and divergent approach to spirocyclic pyrrolidines
Benjamin D. A. Shennan, P. W. Smith, Yusuke Ogura, Darren J. Dixon
Abstract
a [3 + 2]-cycloaddition followed by the condensation of a phosphonate ester, introducing multiple points of divergence. The synthetic utility of this protocol has been demonstrated in the synthesis of a broad family of 1-azaspiro[4,4]nonanes and in a concise formal synthesis of the natural product (±)-cephalotaxine.
Topics & Concepts
Modular designCombinatorial chemistryChemistryComputer scienceProgramming languageAsymmetric Synthesis and CatalysisAdvanced Synthetic Organic ChemistrySynthetic Organic Chemistry Methods