On structural and practical identifiability: Current status and update of results
Mio Heinrich, Marcus Rosenblatt, Franz-Georg Wieland, Hans Stigter, Jens Timmer
Abstract
Identifiability of parameters in dynamical systems is a fundamental concept of mathematical modelling in systems biology and systems medicine. Both the structurally inherent identifiability of parameters in models and the practical identifiability of parameters, which arises from insufficient available data, play crucial roles in the development of useful models. Here, we provide an overview of recent developments in the field of structural identifiability analysis of models based on ordinary differential equations, emphasising its importance for accurate parameter estimation. We extend an existing benchmark study by comparing the methods for structural identifiability analysis with the recently developed StrucID , showing it to be a fast, efficient and intuitive algorithm. Furthermore, this review highlights the challenges in practical identifiability analysis and the need for benchmarking with real-world models using experimental data. The potential benefits of standardising documentation for benchmarking models with experimental data and practical non-identifiabilities are stressed.