Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1
Zhen Yang, Xinpeng Liu, Jun Zhu, Yangyang Chai, Boyi Cong, Bo Li, Wan-Feng Gao, Ye Hu, Mingyue Wen, Yanfang Liu, Li Fu, Xuetao Cao
Topics & Concepts
Gene knockdownCancer researchCancer immunotherapyImmunotherapyImmune systemCancer cellCD28BiologyCytotoxic T cellCD8CancerT cellImmunologyIn vitroCell cultureBiochemistryGeneticsCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionImmunotherapy and Immune Responses