RETRACTED: Oncogenic Role of Long Noncoding RNAMALAT1 in Thyroid Cancer Progression through Regulation of the miR-204/IGF2BP2/m6A-MYC Signaling
Mao Ye, Shu Dong, Hai‐Tao Hou, Tao� Zhang, Minghai Shen
Abstract
validation using xenograft mice. Our data indicated that MALAT1 and IGF2BP2 were highly expressed, while miR-204 was poorly expressed in TC. IGF2BP2 was verified as a target of miR-204. MALAT1 was found to upregulate IGF2BP2 and enhance MYC expression via m6A modification recognition by competitively binding to miR-204, conferring a stimulatory effect on proliferation, migration, and invasion of TC cells, which was accompanied by weakened tumor growth and cell apoptosis. Altogether, the central findings of our study suggest that MALAT1 contributes to TC progression through the upregulation of IGF2BP2 by binding to miR-204.
Topics & Concepts
MALAT1BiologymicroRNALong non-coding RNADownregulation and upregulationCancer researchCell biologyGeneticsGeneRNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing