Editorial: Application of Plant Secondary Metabolites to Pain Neuromodulation
Rajeev K. Singla, Adriana Gibara Guimarães, Gökhan Zengin
Abstract
Pain is a highly unpleasant and intolerable condition, which is associated with multiple diseases and disorders, including but not limited to cancer, diabetes, infectious diseases, neurological and dysfunctional disorders, etc Further, tissue damage or chronic disease of the somatosensory nervous system cause neuropathic pain, which impacts and disturbs life to a higher extent Natural resources especially plants have served and contributed several potential drugs for the alleviation and treatment of pain, either directly or in the derived form For instance, the standard drugs like morphine, cannabidiol, acetylsalicylic acid are some of the key examples gifted by the nature. Even regular and healthy dietary food contains many phenolic compounds that elicit the potential to be anti-inflammatory Thus, in the present research topic, we further emphasized and collected the articles which fill the knowledge gap in this domain. They briefed about the endocannabinoids like anandamide, 2-arachidonoyl glycerol, etc where the former was regulating the appetite and energy balancing while the latter was more involved in the general hunger signal Further, they have also elaborated why menthol, an important phytoconstituent of peppermint oil is effective in IBS treatment.