L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis
Hemant Joshi, Alison Almgren‐Bell, Edgar Anaya, Elizabeth M. Todd, Steven J. Van Dyken, Anushree Seth, Katherine M. McIntire, Srikanth Singamaneni, Fayyaz S. Sutterwala, Sharon Celeste Morley
Abstract
mice display resistance to bleomycin-induced lung injury and fibrosis. These findings identify the LPL-Pyk2-ASC pathway as a target for modulation in NLRP3-mediated inflammatory conditions.
Topics & Concepts
InflammasomeBleomycinFibrosisPulmonary fibrosisLung fibrosisLungCell biologyChemistryCancer researchMedicineImmunologyBiologyInflammationPathologyGeneticsInternal medicineChemotherapyInflammasome and immune disordersInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisGenital Health and Disease