Novel usage of 2-BTSO<sub>2</sub>CF<sub>2</sub>H for metal-free electrophilic difluoroalkanethiolation of indoles
Jun Wei, Kun Bao, Yuan Wang, Rong Sheng, Jinbo Hu
Abstract
The electrophilic difluoromethylthiolation of indoles with 2-BTSO2CF2H is developed. In the presence of (EtO)2P(O)H and TMSCl, the reaction proceeded under mild conditions to give products in modest to high yields. This is a new application of 2-BTSO2CF2H for electrophilic difluoromethylthiolation.
Topics & Concepts
ElectrophileChemistryElectrophilic substitutionMetalCombinatorial chemistryElectrophilic additionMedicinal chemistryOrganic chemistryCatalysisFluorine in Organic ChemistryInorganic Fluorides and Related Compounds