In vitro and in vivo cardiac toxicity of flavored electronic nicotine delivery systems
Obada Abou-Assali, Mengmeng Chang, Bojjibabu Chidipi, J.L. Martínez-de-Juan, Michelle Reiser, Manasa Kanithi, Ravi Soni, Thomas V. McDonald, Bengt Herweg, Javier Sáiz, Laurent Calcul, Sami F. Noujaim
Abstract
The use of electronic nicotine delivery systems (ENDS) is not harm free. It is not known whether ENDS negatively affect cardiac electrophysiological function. Our study in cell lines and in mice shows that ENDS can compromise cardiac electrophysiology, leading to action potential instability and inducible ventricular arrhythmias. Further investigations are necessary to assess the long-term cardiac safety profile of ENDS products in humans and to better understand how individual components of ENDS affect cardiac toxicity.
Topics & Concepts
VanillinChemistryIn vivoNicotinePharmacologyAldehydeAnesthesiaMedicineBiochemistryInternal medicineBiologyBiotechnologyCatalysisSmoking Behavior and CessationNicotinic Acetylcholine Receptors StudyHeart Rate Variability and Autonomic Control